Catharanthus roseus (L.) G.Don

First published in Gen. Hist. 4: 95 (1837)
This species is accepted
The native range of this species is E. & S. Madagascar. It is a subshrub or shrub and grows primarily in the seasonally dry tropical biome. It is used as animal food, a poison and a medicine, has environmental uses and for food.


Bernal, R., Gradstein, S.R. & Celis, M. (eds.). 2015. Catálogo de plantas y líquenes de Colombia. Instituto de Ciencias Naturales, Universidad Nacional de Colombia, Bogotá.

Cultivada en Colombia; Alt. 100 - 2000 m.; Andes, Islas Caribeñas, Llanura del Caribe, Pacífico, Valle del Cauca, Valle del Magdalena.
Morphology General Habit
Hierba, arbusto

Bernal, R., G. Galeano, A. Rodríguez, H. Sarmiento y M. Gutiérrez. 2017. Nombres Comunes de las Plantas de Colombia.

alhelí, buenastardes, caraqueña, cartagena, chocolata, colegiala, corazón de Jesús, corte, cortejo, cortés, cortesita, margarita, moradita, nazarena, niñabonita, pensamiento, primavera, princesa, princesita, reina, sietecueros, vinca, viuda, viudita

Kew Species Profiles

General Description
Madagascar periwinkle is a popular ornamental plant found in gardens and homes across the world, and is used in the treatment of cancer.

Madagascar periwinkle is a popular ornamental plant found in gardens and homes across the warmer parts of the world. It is also known as the source of chemical compounds used in the treatment of cancer. Their discovery led to one of the most important medical breakthroughs of the twentieth century.

The flowers are adapted to pollination by a long-tongued insect, such as a moth or butterfly. This species is also able to self-pollinate. Self-compatibility and a relatively high tolerance to disturbance have enabled the plant to spread from cultivation and to become naturalised in many parts of the world. As a consequence, Madagascar periwinkle is sometimes considered to be an invasive weed, although it does not normally proliferate sufficiently to eliminate native vegetation. Its seeds have been seen to be distributed by ants.

Species Profile
Geography and distribution

Madagascar periwinkle is indigenous to Madagascar, but is cultivated and naturalised throughout the tropics and parts of the subtropics.


Overview: A tender, perennial plant which grows as a herb or subshrub sprawling along the ground or standing erect (30 cm to 1 m in height).Like many other plants in the Apocynaceae family, the sap is a milky latex.

Flowers: It has attractive white or pink flowers comprising five petals spreading from a long, tubular throat.

Leaves: The leathery, dark green leaves are arranged in opposite pairs.

Fruits: Each fruit is made up of two narrow, cylindrical follicles which house numerous grooved seeds. 



In traditional medicine, Madagascar periwinkle has been used to treat a variety of ailments in Madagascar as well as in other parts of the world where the plant has naturalised.

Whilst researching the anti-diabetic properties of the plant in the 1950s, scientists discovered the presence of several highly toxic alkaloids in its tissues. These alkaloids are now used in the treatment of a number of different types of cancer, with one derived compound, called vincristine, having been credited with raising the survival rate in childhood leukaemia from less than 10% in 1960 to over 90% today. Powerful medicinal plants such as the Madagascar periwinkle remind us of the need to conserve and study the increasingly threatened plant habitats of the world.


Madagascar periwinkle is grown as a bedding plant in tropical regions and cultivated indoors as a house plant in temperate areas.

Threats and conservation

Madagascar's forests have been heavily impacted by human activity, but Madagascar periwinkle's ability to thrive in disturbed areas has enabled it to survive in its island home. Furthermore, it is widely established in the wild throughout tropical regions of the world, commonly cultivated in gardens and homes, and grown commercially for the pharmaceutical industry. Given the modern ubiquity of naturalised and cultivated populations of Madagascar periwinkle, direct conservation measures are a low priority for this species.

A rainforest cure for cancer?

Madagascar periwinkle was for many years grown simply as an attractive bedding plant in tropical areas. It comes in a range of pinks and reds that give rise to its other common name, rosy periwinkle. But today it has a more serious purpose; planted around the world during colonial times, it quickly became known at the same time as a useful folk medicine for diabetics. American and Canadian researchers during World War Two became aware that soldiers stationed in the Philippines were using it instead of insulin during shortages.

As a consequence, after the war, lab testing was done in earnest on Madagascar periwinkle. This revealed that the plant contained thirty alkaloids, strong plant chemicals that might be of use to humans. The leaves were found to contain two particularly valuable alkaloids, vinblastine and vincristine. These alkaloids work by disrupting part of cell division or 'mitosis', stopping the process when newly copied DNA is split into two identical parts to produce two identical new cells.

The drug company Eli Lilly tested the new chemicals on mice and found they helped to combat cancers, in particular those of the bone marrow such as childhood leukaemia and non-Hodgkin's Lymphoma. They developed an effective chemotherapy treatment, and today the prognosis for sufferers has changed from a one in ten chance of survival, to at least an eight out of ten chance of some remission.

Contracts and collecting

Madagascar periwinkle shows how important it is to preserve areas of rich biodiversity, for there may be other 'miracle drugs' contained in plants just waiting to be discovered. But it also epitomises the issues involved in exploiting the riches of the plant world. In the 1960s, when these alkaloids were discovered, rich Western countries saw little need to reward the original homeland of the periwinkle, Madagascar, for the riches that had been earned from the plant.

Today at Kew we take a different view. We believe that Madagascar's people should have a say over how their plant resources are exploited: particularly where a plant is restricted to a single country. The Convention on Biological Diversity, of which the UK is a signatory, states that rights to exploit a discovery like that of the alkaloids in the periwinkle should be shared fairly.

In practice, this means that Kew has a legal team whose job is it to make sure that things are done equitably. Before a plant collecting team can even book flights, contracts are drawn up to ensure that the country being visited is happy with the arrangements being made. With such contracts in place, local people have much more incentive to look after their biodiversity. Now they know that if a profitable discovery is made, they will have a share in it.

Millennium Seed Bank: Seed storage

Kew's Millennium Seed Bank Partnership aims to save plant life worldwide, focusing on plants under threat and those of most use in the future. Seeds are dried, packaged and stored at a sub-zero temperature in our seed bank vault.

A collection of  Catharanthus roseus  seeds is held in Kew's Millennium Seed Bank based at Wakehurst in West Sussex.

See Kew's Seed Information Database for further information on Catharanthus roseus seeds


Madagascar periwinkle is easy to cultivate, and can be propagated by seed or by cuttings, but is sensitive to over-watering. A tender plant, it does not withstand frosts and is best grown indoors in temperate climates. It thrives in hot and humid environments, in full sun or partial shade and flowers all year round in hot climates.

Catharanthus roseus is easily propagated by apical semi-ripe cuttings in light, free-draining compost. The best results are obtained when bottom heat and high humidity are provided. Propagation can also be carried out by seed, which should be maintained at 22-25ºC and kept in the dark until the seeds germinate.

This species at Kew

Madagascar periwinkle can be seen growing in the Palm House at Kew.

Preserved specimens of Catharanthus roseus are held in Kew's Herbarium and also the Economic Botany Collection, where they are available to researchers by appointment. 

On sand and limestone soils in woodland, forest, grassland, and disturbed areas.
Not yet assessed according to IUCN Red List criteria.

As with other members of the Apocynaceae family, the sap is extremely toxic.


M. Thulin et al. Flora of Somalia, Vol. 1-4 [updated 2008]

Madagascar periwinkle (English).
Morphology General Habit
Subshrub, up to about 1 m high; stems glabrous or pubescent
Morphology Leaves
Leaf-blades elliptic to obovate, 3–8.5 x 0.8–4 cm, obtuse or acute at the apex, pubescent or glabrous
Morphology Reproductive morphology Flowers Corolla
Corolla white or pink, usually with a darker centre; tube 22–30 mm long; lobes overlapping to the left in bud
Morphology Reproductive morphology Flowers Androecium Stamens
Stamens included; anthers 2.3–3 mm long, subsessile
Morphology Reproductive morphology Flowers Gynoecium Style
Style 16–27 mm long
Morphology Reproductive morphology Fruits
Fruit green, of two cylindrical striate follicles c. 2–4 cm long
Morphology Reproductive morphology Seeds
Seeds black.
Originating from Madagascar but cultivated and naturalized all over the tropics.

Biogeografic region: Andean, Caribbean, Pacific. Elevation range: 100–2000 m a.s.l. Cultivated in Colombia. Colombian departments: Antioquia, Bogotá DC, Bolívar, Caldas, Casanare, Cauca, Cundinamarca, Magdalena, Nariño, San Andrés y Providencia, Santander, Sucre, Tolima, Valle del Cauca.
Herb, Shrub.
Habitat according IUCN Habitats Classification: forest and woodland, savanna, shrubland, native grassland, artificial - terrestrial.

Extinction risk predictions for the world's flowering plants to support their conservation (2024). Bachman, S.P., Brown, M.J.M., Leão, T.C.C., Lughadha, E.N., Walker, B.E.

Predicted extinction risk: not threatened. Confidence: confident

George R. Proctor (2012). Flora of the Cayman Isands (Second Edition). Royal Botanic Gardens, Kew

Morphology General Habit
An erect herb usually less than 50 cm tall, more or less finely pubescent throughout
Morphology Leaves
Leaves oblong or elliptic-oblong, mostly 2–7 cm long, obtuse and apiculate at the apex
Morphology Reproductive morphology Flowers
Flowers in axillary pairs, subsessile; calyx-lobes 3–5 mm long; corolla white or pink, or white with a pink eye, the tube ca. 2.5 cm long, the lobes broadly obovate, 1.5 cm long
Morphology Reproductive morphology Seeds
Follicles pubescent, longitudinally ribbed, 1.5–3.5 cm long, 2–3 mm thick.
Cayman Islands. Originally described from Madagascar, now cultivated and escaping in nearly all warm countries.

Chocolata, Cortejo


Medicinal, ornamental.

Cultivated as an ornamental Some of the alkaloids of C. roseus are used for the treatment of leukaemia in children.

Use Animal Food
Used as animal food.
Use Environmental
Environmental uses.
Use Gene Sources
Used as gene sources.
Use Food
Used for food.
Use Materials
Used as material.
Use Medicines
Medical uses.
Use Poisons

Common Names

Madagascar Periwinkle, Madagascar periwinkle


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